After the independence on 14th August, 1947, many eminent homoeopaths settled in Karachi and Hyderabad, whereas Karachi became the center of homoeopathic activities. Some homoeopaths took the initiative and the Pakistan Homoeopathic Association was formed but this Association was very short-lived. Another body, Pakistan Homoeopathic Federation was formed in 1949, at Karachi. The first Pakistan Homoeopathic conference was held under the auspices of the Federation in Sept. 1949 at Karachi. For 18 years after the creation of Pakistan, homeopathy was practiced widely but remained officially unrecognized. 

In 1950, Dr. M. Ismail Nami formed a non-governmental society namely "Khalid Memorial Welfare Society". This society became the milestone through which various educational, welfare and social services were being provided on regular basis to the poor and needy people of Hyderabad. Under this Society four separate high schools, for girls and boys, one primary school and one oriental college was successfully running at that time.

In 1965, the Government passed an act under which homeopathy and the indigenous herbal systems of medicine were regulated. Homeopaths wishing to continue their practice were assessed by a Government nominated Board of Senior homeopaths. All practitioners with sufficient experience and knowledge of the system were formally registered and allowed to continue their practice.

It was in 1965, when Dr. M. Ismail Nami felt the need of Homoeopathic education to be introduced in Hyderabad city, which motivated him to laid the foundation of Sindh Homoeopathic Medical College and Hospital. In 1972, the Government of Pakistan took a step to nationalized all the educational institutions. Due to this, the doors for progress were closed on the SHMCH. 

Dr. M. Ismail Nami, then took constructive action and after some struggle was successful to obtain a separate building, from the Government of Pakistan, in Gurunagar, Hyderabad. 

In October 1979, with the efforts of Dr. M. Ismail Nami, a homoeopathic clinic and dispensary was established in the college premises, for the community people, to provide basic health facilities through Homoeopathic Medicines. Moreover, this clinic is also helpful in providing practical training to the students of final year, who are required to spend six months house job period as part of their studies.

On April 21, 1980, Dr. M. Ismail Nami, the founder of Sindh Homoeopathic Medical College & Hospital passed away from this world (God Bless His Soul) leaving the beacon of hope for the people of Sindh. 

Since 1980, the college is run by Dr. M. Farouk Ismail Nami, son of late Dr. M. Ismail Nami, who is at present the Principal of diploma campus and Head of the degree campus. Under the leadership of Dr. M. Farouk Ismail Nami his team of dedicated personnel is responsible for the smooth running of both these Institutions.

Today, the college provide a rigorous grounding in medical sciences as well as incorporating diverse healing philosophies, holistic counseling and an integrated approach to the cause of disease, assuming the interdependence of mind, body and spirit. The college offers exceptional teaching and training programs for those wishing to become practicing homeopaths, with courses being taught at the Diploma and Degree campuses in Hyderabad, Sindh, Pakistan.